Mergeomics: integration of diverse genomics resources to identify pathogenic perturbations to biological systems
نویسندگان
چکیده
Le Shu, Yuqi Zhao, Zeyneb Kurt, Sean Geoffrey Byars , Taru Tukiainen, Johannes Kettunen, Samuli Ripatti, Bin Zhang, Michael Inouye 3, , Ville-Petteri Mäkinen*, Xia Yang* Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA Center for Systems Genomics, University of Melbourne, Australia School of BioSciences, University of Melbourne, Australia Institute of Molecular Medicine, Finland Department of Genetics and Genomics Sciences, Mount Sinai School of Medicine, NY, USA Department of Pathology, University of Melbourne, Australia South Australian Health and Medical Research Institute, Adelaide, Australia School of Biological Sciences, University of Adelaide, Adelaide, Australia Institute of Health Sciences, University of Oulu, Oulu, Finland
منابع مشابه
Creation the fully integrated and flourishing assessment challenge award: Integration is the key
Medicine is now undertaking a paramount revolution that will alter the nature of healthcare from reactive to proactive. It is imperative to integrate experimental and computational investigation in order to appreciate complex biological systems in the era of precision medicine. In light of this revolution, we necessitate to precision medicine means such as systems approaches (genomics, radiogen...
متن کاملAnalysis of adaptation determinants of domestic rainwater harvesting systems (DRWHs) in Golestan Province, Iran
Most residences of the northern parts of Golestan Province, have historically used rooftop rainwater for drinking. Its adoption rate and continued use have declined in recent years for various reasons. Based on a survey of 380 cases, this research attempted to identify what factors are contributing to the adoption of these systems. The results demonstrated that the adoption changes in response ...
متن کاملSystems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine.
A grand challenge impeding optimal treatment outcomes for patients with cancer arises from the complex nature of the disease: the cellular heterogeneity, the myriad of dysfunctional molecular and genetic networks as results of genetic (somatic) and environmental perturbations. Systems biology, with its holistic approach to understanding fundamental principles in biology, and the empowering tech...
متن کاملAdvances in Omics and Bioinformatics Tools for Systems Analyses of Plant Functions
Omics and bioinformatics are essential to understanding the molecular systems that underlie various plant functions. Recent game-changing sequencing technologies have revitalized sequencing approaches in genomics and have produced opportunities for various emerging analytical applications. Driven by technological advances, several new omics layers such as the interactome, epigenome and hormonom...
متن کاملArtificial intelligence & genetics
Artificial intelligence (AI) is the development of computer systems that are able to perform tasks that normally require human intelligence. Artificial intelligence (AI) is a wide-ranging tool that enables people to rethink how we integrate information, analyze data, and use the resulting insights to improve decision making—and already it is transforming every walk of life. AI has application...
متن کامل